Cellular Organization, Computational, and Experimental Studies of Microtubule Dynamics and Regulation by Binding Proteins

The long-term goal of this project is to develop a predictive and quantitative understanding of the MT cytoskeleton and its regulation by MTBPs, which will impact fields ranging from systems biology to nanotechnology. The flexible model and tutorials developed through this project will allow researchers to develop and test specific hypotheses about the mechanisms of dynamic instability and MTBP action, which will in turn help design and direct future experiments. More broadly, it will help students and researchers at all levels gain an intuitive understanding of dynamic MT systems.


  • Drs. Mark Alber and Holly Goodson (ACMS and Department of Biochemistry, Notre Dame)












Click on the image below to begin the simulation: