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Mon Sep 24, 2018

Charles Edison Lecture: Xuming He, Department of Statistics, University of Michigan

4:30 PM - 5:30 PM
105 Jordan Hall of Science

Image

Xuming He, Department of Statistics, University of Michigan, will give a Charles Edison Lecture colloquium titled, "Quantile Regression and Data Augmentation" at 4:30 PM in 105 Jordan Hall of Science.

Abstract

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Tue Sep 25, 2018

ACMS Statistics Seminar: Simon Birrer

3:30 PM - 4:30 PM
154 Hurley Hall

Simon Birrer
UCLA

3:30 PM
154 Hurley Hall

Probing Dark Matter and Dark Energy With Strong Gravitational Lensing - A Statistics Challenge View

Gravitational lensing is a unique phenomena to probe the composition and scales of our universe and as such to shed light on the unknown physics of dark matter and dark energy.…

Posted In: Statistics Seminar

BioPhysics Seminar: Michael Harms, University of Oregon

4:00 PM - 5:00 PM
127 Hayes-Healy

“Evolutionary Biophysics”
 
Michael J Harms, Chemistry & Biochemistry, Institute of Molecular Biology, University of Oregon
 
Abstract:
 

How does protein biochemistry shape protein evolution?  How do new biochemical features evolve?  To answer these questions, the Harms lab studies protein evolution using phylogenetic analyses, computational and experimental studies of protein “sequence space”, and rigorous studies of protein biochemistry.  I will discuss two ongoing projects.  In the first, we ask the deceptively simple question: why can’t we predict the combined effect of mutations by summing their individual effects?  Through a set of computational and experimental studies, we demonstrate that universal thermodynamic considerations explain why mutations do not combine additively.  Inspired by these results, we are developing quantitative, mechanistic models to account for non-additivity between mutations—potentially leading to predictive models of protein evolution.  In the second project, we are investigating the evolution of the innate immune protein S100A9.  This protein can exist as either a pro-inflammatory homodimer or as an antimicrobial heterodimer with the protein S100A8. We found that the heterodimer arose from an ancient homomeric interface that was maintained after gene duplication.  The key historical mutations that conferred inflammatory and antimicrobial activity have different effects when introduced into the homodimer versus the heterodimer.  This allowed a small protein to acquire new functions without compromising existing functions.  We suspect this may be a general mode my which multifunctional proteins evolve.

Fri Sep 28, 2018

ACMS Colloquium: Zifeng Zhao, Mendoza College of Business, University of Notre Dame

4:15 PM - 5:15 PM
127 Hayes-Healy Center

Zifengzhao Photo

Zifeng Zhao, Mendoza College of Business, University of Notre Dame, will give a colloquium titled, "A Composite Likelihood-based Approach for Change-point Detection in Spatiotemporal Process" at 4:15 PM in 127 Hayes-Healy Center.

Abstract

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Mon Oct 29, 2018

ACMS Colloquium: Sudipto Banerjee, Department of Biostatistics, UCLA

4:15 PM - 5:15 PM
127 Hayes-Healy Center

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Sudipto Banerjee, Dept. of Biostatistics, UCLA, will give a colloquium titled, "TBD" at 4:15 PM in 127 Hayes-Healy Center.

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Mon Nov 5, 2018

ACMS Colloquium: Yuhong Hang, Department of Statistics, University of Minnesota

4:15 PM - 5:15 PM
127 Hayes-Healy Center

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Yuhong Hang, Dept. of Statistics, University of Minnesota, will give a colloquium titled, "TBD" at 4:15 PM in 127 Hayes-Healy Center.

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Fri Nov 30, 2018

ACMS Colloquium: Catalin Trenchea, Department of Mathematics, University of Pittsburgh

4:15 PM - 5:15 PM
127 Hayes-Healy Center

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Catalin Trenchea, Department of Mathematics, University of Pittsburgh, will give a colloquium titled, "TBD" at 4:15 PM in 127 Hayes-Healy Center.

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Mon Apr 8, 2019

ACMS Colloquium: Christopher Wikle, Department of Statistics, University of Missouri

4:15 PM - 5:15 PM
127 Hayes-Healy Center

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Christopher Wikle, Dept. of Statistics, University of Missouri, will give a colloquium titled, "TBD" at 4:15 PM in 127 Hayes-Healy Center.

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