Doudou Zhou
Harvard University
3:45 PM
127 Hayes-Healy Center
A tea will precede the event at 3:15 pm in 101A Crowley Hall.
Extracting Reliable Real-world Evidence from Multi-institutional EHR Data
The increasing availability of electronic health records (EHR) data offers valuable prospects for biomedical research, enhancing patient care. However, leveraging this data from diverse healthcare systems to provide unbiased, precise decision-making information is a complex task due to varied coding systems, patient populations, and healthcare delivery models. This talk will first cover automated data harmonization using representation learning, which includes co-training multi-source embeddings through block-wise overlapping noisy matrix completion. This method finds applications in code mapping, feature selection, and knowledge graph construction. The second part of the talk will delve into federated learning applied to reinforcement learning (RL) frameworks, a vital yet under-explored aspect in current studies, for establishing evidence-based dynamic treatment regimes. We will introduce an innovative federated policy optimization algorithm for offline RL that allows for the analysis of site-specific variables, supported by a theoretical framework.
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