**Ruijun Zhao**

**Associate Professor, Minnesota State University
Visiting Associate Professor, University of Notre Dame**

**3:30 PM**

**154 Hurley Hall**

**Management Strategies in Malaria Models Using Optimal Control Theory**

Malaria has been a health problem worldwide for a long time. Malaria causes high mortality among children under age five. Though malaria can be treated with Artemisinin-based anti-malaria drugs, the current effective control of the disease mainly relies on preventive strategies, such as insect-treated bed-nets and indoor residual spray. Recently, a good news in battling malaria is that a promising vaccine, RTS, S will be on the market soon. In this talk, we will propose two mathematical models incorporating the vaccination control, one using system of ordinary differential equations, the other using age-structure partial differential equations. In both cases, we will use the optimal control theory to investigate the best outcomes.

**Full List of Applied Math Seminar Speakers**