ACMS Applied Math Seminar: Kresimir Josic


Location: 154 Hurley Hall

Kresimir Josic
University of Houston

3:30 PM
154 Hurley Hall

Spatio-temporal Dynamics of Synthetic Microbial Consortia

Modeling is essential in the design of genetic circuits with desired properties. I will review several examples where mathematical models have been central to the development and understanding of the dynamic of synthetic organisms. I will focus on synthetic bacterial microconsortia that exhibits emergent oscillatory behavior - when co-cultured, the interaction between two bacterial strains results in population-level transcriptional oscillations. The spatio-temporal dynamics of such consortia, including synchrony between distant parts of the population, depend sensitively on the architecture of the underlying genetic circuits. I will show how simplified mathematical models can help us understand how robust oscillations arise, and how spatially synchronous oscillations are maintained.


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